Source: Clujul Medical. Sep, Vol. Despite this fact, every year there are more than new cases, from which more than will die due to gastric cancer, which makes gastric cancer one of the most deadly neoplasias. Progress has been made regarding the diagnosis, but not in early gastric cancer diagnosis, and with Japan's exception nowadays there are no screening programs gastric cancer new treatment and functional in the European Union' countries or the United States. The last years have showed improvement in the patients' prognosis through modifications of strategy or new treatment techniques.
Hericium erinaceus HE has been used for the treatment of digestive diseases for over years in China. HE possesses many beneficial functions such as anticancer, antiulcer, antiinflammation and antimicrobial effects, immunomodulation and other activities.
The aim of the studies was to evaluate the anticancer efficacy of two extracts HTJ5 and HTJ5A from the culture broth of HE against three gastrointestinal cancers such as liver, colorectal and gastric cancers in both of in vitro of cancer cell lines and in vivo of tumor xenografts and discover the active compounds. Tumor volumes and body weight were measured daily during the first gastric cancer new treatment days and times a week thereafter to assess the tumor growth inhibition, tumor doubling time, partial and complete tumor response and toxicity.
They are more effective and less toxic compared to 5-FU in all four in vivo tumor models. However, further studies are required to find out the active chemical constituents and understand the mechanism of action associated with the super in vivo anticancer efficacy.
In addition, future studies are needed to confirm our preliminary results of in vivo synergistic antitumor efficacy in animal models of tumor xenografts with the combination of HE extracts and clinical used anticancer drugs gastric cancer new treatment as 5-FU, cisplatin and doxurubicin for the treatment of gastrointestinal cancers. This study investigated whether dihydroartemisinin DHAa semi-synthetic derivative of artemisinin, could inhibit the growth of gastric cancer both in vitro and in vivo.
A series of in vitro experiments including MTT, colony-forming, wound healing, invasion, cell cycle, cellular senescence, and apoptosis assays were performed to examine the antiproliferative and antimetastatic effects of DHA on three gastric cancer cell lines, SGC, BGC, and MGC The result gastric cancer new treatment that the proliferation rate and colony-forming abilities of gastric cancercells were significantly suppressed causes for nasal papilloma DHA gastric cancer new treatment with significant suppression of the expressions of proliferation markers PCNA, cyclin E, and cyclin D1and upregulation of p21 and p Moreover, DHA induced cellular senescence, G1 phase cell gastric cancer new treatment arrest and hindered the migration and invasion of gastric cancer cells corresponding with downregulation of MMP-9 and MMP Treatment of gastric cancer cells with DHA increased miRb gastric cancer new treatment miR expression, caused a downregulation of Bcl-2, resulting in apoptosis of gastric cancer cells.
Gastric cancer new treatment summary, we have shown that DHA is able to inhibit the growth and metastasis of human gastric cancer. Our work suggested that DHA has significant anticancer effects against gastric cancer both in vivo and in vitro, indicating that it is a promising therapy for human gastric cancer.
Resveratrolul este un polifenol apărut pe cale naturală cu puternică acţiune de inducere a apoptozei.
Gastric Cancer Overview - Mayo Clinic
Cu toate acestea mecanismele care stau la baza acţiunilor sale rămân necunoscute. Aceste date furnizează probe că resveratrolul induce apoptoza via ROS, gastric cancer new treatment independent de gastric cancer new treatment, la linia celulară a cancerului gastric uman SGC Acest studiu investighează faptul dacă dihidroartemisininul DHAun derivat semi-sintetic al artemisininului, poate inhiba dezvoltarea cancerului gastric atât in vivo cât şi in vitro.
Au fost desfăşurate o serie de experimente in vitro, incluzând MTT, formarea de colonii, vindecarea unor răni, invazie, ciclu celular, îmbătrânire celulară şi teste de apoptoză, pentru a examina efectele anti-proliferative şi anti-metastatice ale DHA asupra a trei linii celulare ale cancerului gastric, SGC, BGC şi MGC Rezultatele au arătat că rata de proliferare şi abilitatea de a forma colonii ale celulelor canceroase gastrice au fost semnificativ supresate de DHA odată cu o supresare semnificativă a expresiei markerilor de proliferare PCNA, ciclina E şi ciclina D1 şi hiperreglarea lui p21 şi p Mai mult decât atât, DHA a indus senescenţă celulară, stoparea ciclului celular în faza G1 şi a împiedicat migraţia şi invazia celulelor canceroase gastrice cu hiporeglarea lui MMP-9 şi MMP Tratamentul celulelor gastrice cu DHA a crescut expresia miRb şi miR şi a cauzat o hiporeglare a Bcl-2, rezultând apoptoza gastric cancer new treatment canceroase gastrice.
În rezumat am arătat că DHA este capabil să inhibe dezvoltarea şi metastazele cancerului gastric uman. Munca noastră sugerează că DHA are efecte semnificative anti-cancer asupra cancerului gastric atât in vivo cât şi in vitro, indicându-l ca pe un tratament promiţător pentru cancerul gastric la oameni.