Published19 Jan Abstract The noninvasive diagnosis of the malignant tumors is an important issue in research nowadays.
Abdominal cancer symptoms signs
Our purpose is to elaborate computerized, texture-based methods for performing computer-aided characterization and automatic diagnosis of these tumors, using only the information from ultrasound images. In this paper, we considered some of the most frequent abdominal malignant tumors: the hepatocellular carcinoma and the colonic tumors. We compared these structures with the benign tumors and with other visually similar diseases. Besides the textural features cancer abdominal area proved in our previous research to be useful in the characterization and recognition of the malignant tumors, we improved cancer abdominal area method by using the grey level cooccurrence matrix and cancer abdominal area edge orientation cooccurrence matrix of superior order.
As resulted from our experiments, the new textural features increased the malignant tumor classification performance, also revealing visual and physical properties of these structures that emphasized the complex, chaotic structure of the corresponding tissue.
The colorectal tumors also represent a frequent disease for the population of antihistaminicele sunt viermi developed countries. The golden standard for cancer diagnosis is the biopsy, but this is an invasive, dangerous method that can lead to the spread of the tumor inside the human body.
Intrebarile provin de la pacienti 1. Toti bolnavii cu ascita se trateaza la fel? Ascita se trateaza diferit, in functie de cauza ei.
A non-invasive, subtle analysis is due, in order to detect the cancer in early evolution stages, when the tumor can be surgically removed. We perform this study by using computerized methods applied on ultrasound images. Other types of image acquisition techniques, such as computer tomography CTmagnetic resonance imaging MRIand endoscopy are cancer abdominal area invasive or expensive.
The texture is an important feature, as it provides subtle information concerning the pathological state of the tissue, overcoming the accuracy of the human perception, through the statistical and multiresolution approaches.
The texture-based methods in combination with classifiers were widely used in the domain of malignant tumor characterization and recognition from medical images. In [ 2 ], Raeth used the textural features in order to distinguish the normal liver cancer abdominal area the diffuse liver diseases and from the malignant liver tumors.
The features derived from the second-order grey levels cooccurrence matrix, from the edge cooccurrence matrix, as well as other edge and gradient-based features, speckle cancer abdominal area distribution parameters, and the Fourier power spectrum, provided satisfying results concerning the differentiation between the tumoral and nontumoral tissue.
In [ 3 ] the authors computed the first-order statistics the mean grey level and the grey level variancethe second-order grey level cooccurrence matrix parameters and run-length matrix parameters which were used in combination with an artificial neural networks based classifier, as well as with cancer abdominal area classifier based on linear discriminants in order to differentiate the malignant liver tumors from hemangioma and from the normal liver.
The resulted recognition rate was The wavelet transform was also implemented [ 4 ], in order to perform a multi-resolution analysis of the textural features. In [ 5 ] the authors analyzed the fluorescent images of the colonic tissue based hpv vaccine meaning textural parameters derived from the second order grey level cancer abdominal area matrix GLCMin order to distinguish the colonic healthy mucosa versus adenocarcinoma.
However, a systematic study concerning the most relevant textural features that best characterize the malignant tumors and of the most appropriate methods that lead to an increased diagnosis accuracy is not done.
aprilie | | Dr Ditoiu, medic specialist gastroenterolog-hepatolog in Bucuresti
We perform this in our work by building the imagistic textural model of the malignant tumors. We previously defined the imagistic textural model of the malignant tumors [ 6 ], consisting in the most relevant textural features able to separate the HCC tumor from the visually similar tissues cirrhotic parenchyma, benign tumorstogether cancer abdominal area their cancer abdominal area values mean, standard deviation, and probability distribution.
In this work, we analyzed new methods for textural features computation, based on the superior order grey cancer abdominal area cooccurrence matrix GLCM [ 7 ], respectively on the superior order edge orientation cooccurrence matrix EOCMthe purpose being to improve the characterization of the abdominal malignant tumors, and to increase the automatic diagnosis accuracy.
Cancer abdominal area this way, we expect to get a more subtle evaluation procedure than in the case of using the other textural features. The third-order GLCM was experimented for the analysis of the trabecular bones in proximal femur radiographs [ 8 ], as well as for crop classification [ 9 ], but it was never implemented for tumor characterization and recognition.
Femeia asta are un abdomen acut cu distorsiuni musculare! This woman has immediate postprandial upper abdominal distention. Avem un caz acut de distensiune abdominală superioară. Propune un exemplu Diarrhea symptoms often include abdominal distention and sickness. Diaree Simptomele includ adesea distensie abdominală şi boală.
There are no important realizations in the image analysis domain involving the fifth-order GLCM matrix. The second order EOCM was implemented by Raeth in [ 2 ] for malignant tumor contour characterization and provided satisfying results in this domain. The third order EOCM was not previously implemented.
Thus, we analyzed the role that the second- third- and fifth-order GLCM, respectively, the second- and third-order EOCM have, concerning both the subtle characterization of HCC and colonic tumor tissue, as well as the automatic diagnosis of these types of cancer.
Extended Haralick features were defined for cancer abdominal area characterization of cancer abdominal area tumor cancer abdominal area, and the best orientations of the corresponding displacement vectors were determined in both cases of the superior order GLCM and EOCM. The edge orientation variability feature was also defined in order to characterize the complex structure of cancer abdominal area tumor tissue.
The malignant tumors were compared with visually similar tissues. The HCC tumor was compared with the cirrhotic liver parenchyma on which it had evolved and with the benign cancer abdominal area tumors. The colonic tumors were compared with the inflammatory bowel diseases IBDas they share, in ultrasound images, many visual characteristics with these affections.
The assessment helmintox sachet et allaitement the relevant textural features for the characterization of the malignant tumors was also performed, through specific methods such as the correlation-based feature selection CFS [ 10 ] and through the evaluation of the individual attributes based on their information gain with respect to the class [ 10 ].
Powerful classifiers that gave the best results in our former pancreatic cancer under 45 [ 6 ], such as the multilayer perceptron [ 11 ] and the support vector machines SVM [ 11 ], as well as the AdaBoost combination scheme [ 11 ], were adopted for the evaluation of the textural model and of the recognition accuracy.
The correlation of the textural features with the internal structure and with the properties of the tumor tissue was also discussed. Materials and Methods 2. Materials and Working Methodology In our study, mainly the patients suffering from HCC and colonic tumors were taken into consideration. Patients affected by benign liver tumors such as hemangioma and focal nodular hyperplasia FNH were also considered, being known that these tumors have a similar visual aspect with HCC in many situations.
Subjects suffering from inflammatory cancer abdominal area diseases IBD were taken into account as well, because these affections provided a similar visual aspect of the bowel walls like those provided by the colorectal tumors. All these patients were previously biopsied.
Abdominal cancer ascites
For each patient, multiple images were acquired, corresponding to various orientations of the transducer, using the same settings of the ultrasound machine. The same number of cancer abdominal area was considered for each patient, as described in the experimental section.
B-mode ultrasonography was used, in order to preserve the textural properties of the tissues. Rectangular regions of interest were selected inside the tumors, on the liver tissue, or on the bowel wall, in areas which were not affected by artifacts. Then, the imagistic textural model of the malignant tumors was built according to the steps below, and the role of the new derived textural features in cancer abdominal area the accuracy of the malignant tumor characterization medicamente pentru paraziți pe cap recognition performance was analyzed.
The Imagistic Textural Model of the Malignant Tumors and the Phases Due for Model Building The imagistic textural model of HCC consists of the set of relevant, independent textural features, able to distinguish this tumor from the cirrhotic liver parenchyma and from the benign tumors.
Abdominal cancer signs Traducere "upper abdominal" în română, Abdominal cancer symptoms signs
The specific, statistical values of the textural features—mean, standard deviation, and probability distribution—are part of the model. The mathematical description of the imagistic textural model is given below. Let be the space of the potentially relevant textural features, containing a number of such features: Cancer abdominal area features from are considered in their initial representation, as they appear after applying the image analysis methods.
We define as being the transformed feature space, obtained from the initial feature space,after applying dimensionality reduction methods—mainly feature selection techniques [ 10 ]. The imagistic textural model of the tumor TM consists of a collection of vectorsassociated with each relevant textural featurecontaining the specific values that characterize each analyzed class: The vectors of the imagistic textural model are composed by the specific parameters described by 3where mean the arithmetic mean value and standard deviation are real numbers; the Relevance, represented by an integer, quantifies the importance that the considered textural feature cancer abdominal area in the differentiation between HCC and other kinds of tissues.
In order to generate a reliable imagistic textural model, first, the image selection for the training set building is due. For cancer abdominal area considered type of tissue, a corresponding class is built. Then, an image analysis phase is necessary: the textural feature computation using specific methods for texture analysis is involved in this process.
The values of the cancer abdominal area features are stored in the database cancer abdominal area used for further evaluations. The learning phase is essential in order to perform the relevant feature selection, to eliminate the redundant features and peritoneal cancer ovarian determine the specific, statistical values, and the corresponding probability distributions.
Dimensionality reduction methods consisting of feature selection [ 10 ] and feature extraction techniques [ 11 ] are implemented in this phase. At the end, a validation phase is necessary, involving the evaluation of the generated model by providing the relevant features at the classifiers inputs and estimating the accuracy of each classifier.
Symptoms of Stomach Cancer
A new test set of images, different from the training set, is used in this phase. The phases due in order to build the imagistic textural model are described below. Training Set Building For each patient, three to five images were considered. On each image, rectangular regions of interest were selected on each type of tissue, inside HCC and the colonic tumors, respectively, on the cirrhotic parenchyma on which HCC evolved, as well as inside the benign liver tumors and on the superior part of the bowel wall affected by inflammatory bowel diseases.
Pairs of classes were considered, and then the classes were combined in equal proportions inside the training set. The potentially relevant textural features were determined on the regions of interest, using specific methods for texture analysis, and the corresponding values were stored. An instance of the training set consisted of the values of the considered textural features, computed inside a certain region of interest, followed by the class specification.
Methods Applied during the Image Cancer abdominal area Phase During the image analysis phase, noise reduction was initially performed, by cancer abdominal area an averaging filter [ 12 ].
Then, specific methods for texture analysis were applied, providing the initial set of potentially relevant textural features. We previously computed 48 textural cancer abdominal area, from the following categories: the mean value of the grey levels [ 12 ], the second order grey levels cooccurrence matrix GLCMand cancer abdominal area associated Haralick parameters [ 13 ]—the energy, entropy, correlation, contrast, variance, and local homogeneity that emphasized the global properties of the texture.
Cancer abdominal area and gradient-based statistics [ 12 ], respectively, the frequency and density of the textural microstructures, detected by using the Laws convolution filters were computed as well [ 12 ].
Computational and Mathematical Methods in Medicine
The Shannon entropy [ 14 ], computed after applying the wavelet transform [ 15 ], was also determined. The Haar wavelet transform was applied recursively at two levels of resolution: the low-low, low-high, high-low, and high-high components were derived at the first level, then, the wavelet transform was applied again on each of these cancer abdominal area.
The Shannon entropy cancer abdominal area computed on each resulted component, at both first and second levels. The determined textural features were independent on orientation, as they were computed on multiple directions and the result was averaged. They were also independent of illumination and scaled with the size of the region of interest. In this work, we defined and experimented the third-and fifth order GLCM, respectively, the second-and third order EOCM, for obtaining more refined textural features.
The effect of the new textural features on the improvement of the imagistic textural model of the malignant tumors was carefully analyzed. Description of the Learning Phase During the learning phase, the selection of the relevant textural features was performed.
We considered a feature as being relevant if it emphasized the defining characteristics of the tumor tissue and it substantially contributed to the separation of the tumor tissue from the visually similar tissues. From a more technical point of view, a feature was considered relevant if, by including it in the feature set, it led to an increase in the classification accuracy.
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There are specific methods for feature selection, integrated in two main groups, filters and wrappers [ 10 ], which perform a reliable separation of the relevant features from the nonrelevant ones. We compared, in our previous research [ 6 ], various methods from these categories, as well as their combinations.
Cancer abdominal area best results were obtained when using the methods of correlation-based feature selection CFScombined with erbicid împotriva paraziților search [ 10 ], the information gain attribute evaluation [ 16 ], the consistency-based feature subset evaluation [ 10 ], respectively the wrapper cancer abdominal area used the decision trees as classifier, and the best first search method [ 16 ] for subset finding.
The specific values of the relevant textural features were determined by using confidence intervals and probability distribution tables [ 11 ]. In this cancer abdominal area, we assessed the relevance of the newly obtained textural features, by using the most powerful feature selection methods, being interested in the diagnosis accuracy improvement. Description of medicamente de tratament pentru helmint Validation Phase The validation phase consisted of providing the final set of relevant textural features at the inputs of some powerful classifiers, and in analyzing their effect on the classification process improvement.
Classifiers from different categories, as well as classifier combinations, were compared in cancer abdominal area to obtain the best performance during this phase [ 6 ].
The best results were provided by the methods of support vector machines SVM [ 11 ] with polynomial cancer abdominal area of 3rd degree, by the multilayer perceptron MLPdecision trees C4. The following parameters were used in order to assess the classification performance: the recognition rate percent of correctly classified instancesthe sensitivity TP ratethe specificity TN ratethe area under the ROC curve AUC [ 11 ], and the time due for model building [ 16 ].
Colorectal cancer jaundice stratified cross-validation strategy [ 11 ] was implemented for classification performance evaluation, in order to preserve the original class proportions.
Julesz et al. Haralick [ 18 ] defined the two-dimensional cooccurrence matrix of the grey levels as containing, in its elements, the number of pairs of pixels having two specific values of the intensity, andbeing situated at a distance defined by a displacement vector: Haralick also defined and implemented statistical measures, such as the homogeneity, energy, entropy, correlation, variance, contrast [ 18 ], in order to emphasize the global properties of the texture.
In [ 7 ], Akono et al. He also extended the mathematical expressions of several statistical Haralick measures from order two to ordersuch as the sum of the GLCM elements, the inverse difference, the dissimilarity and the contrast. We defined the GLCM of order in the following manner:.